Axo-glial pathology in Multiple Sclerosis and its effects on neurotransmission: development of a computational model
Richard Reynolds (Medicine)
Aldo Faisal (Bioengineering/Computing)
Kambiz Alavian (Medicine)
Neuroinflammation is a feature of all degenerative disorders of the human brain. In multiple sclerosis and Parkinson’s disease, diffuse inflammation leads to changes at the nodes of Ranvier, the regions of the nerve fibres where the electrical signals are amplified. We do not know how these changes give rise to deficits in nerve conduction and how this can be reversed. This project will use computer modelling, human brain tissue studies and electrical recording from brain slices to investigate how the electrical properties of the nerve fibres could be changed to compensate for this neural damage and reverse the neurological deficit.